Dedryck Boyata will replace the injured Vincent Kompany at the heart of the Belgium defence for their Group G opener against Panama on Monday.
With Kompany and Thomas Vermaelen injured, Boyata was chosen to start in a talent-packed side that includes Manchester City's Kevin De Bruyne, Chelsea's Eden Hazard and Manchester United's Romelu Lukaku.
Panama, who are playing their first ever World Cup match, start with a 4-1-4-1 formation with 37-year old striker Blas Perez, who scored the goal that secured their qualification, leading the line up front.
England and Tunisia are also in Group G and play each other later on Monday.